Principal Associate Scientist, Analytical Development & Operations

The role

This person will lead the development of analytical methods and novel techniques for mRNA and LNP formulations. They will use analytical data to build process understanding and evaluate the impact of process parameters on product quality.

What you will do

• Leads development of analytical methods or novel analytical techniques focusing on deep physical characterization of early/clinical-stage mRNA and LNP formulations.
• Analyzes data and draws conclusions which drive screening, optimization, and scale-up efforts in mRNA and LNP Process Development.
• Apply a strong understanding of mRNA and LNP analytical methods to support identification and characterization of critical process parameters and critical material attributes
• Independently troubleshoot experimental and process challenges using a systematic, data-driven approach.
• Partner closely with Process Development, Manufacturing, MSAT, Quality, and other CMC functions to support process development and characterization activities.
• Evaluates and onboards innovative analytical tools to further RNA/LNP understanding.
• Interfaces with external contract research organizations to ensure compliance with internal timeline and quality requirements.
• Mentors and develops junior scientists in exploring new analytical techniques to further characterize mRNA/LNP therapeutics.
• Maintains electronic notebook records and authors protocols.

Required qualifications

• B.S. or Advanced Degree in Chemistry, Chemical Engineering, Biology, Biochemistry, Molecular Biology or other relevant scientific discipline.
• 5+ years of experience in Analytical and Process Development.
• Working knowledge of common mRNA/LNP analytical methods (Plate-based assays, PCR, UPLC/HPLC, light scattering, and/or capillary gel electrophoresis, etc.)
• Working experience in analytical method development.
• Experience with enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for biologics or nucleic acid therapies.
• Conducting laboratory experiments.
• Excellent documentation review and writing skills.
• Ability to quickly adapt to change and thrive in a dynamic and entrepreneurial early-stage environment.
• A strong team player with excellent oral and written communication skills and a demonstrated ability to work independently.
• Independently motivated, detail oriented and good problem-solving ability.

Nice to have

• experience with a focus on mRNA and/or LNP technology
• Familiarity with advanced analytical technologies, LC-MS, in-line monitoring, automation, digital process development, and/or advanced data analysis techniques
• Understanding of process development, and/or regulatory aspects of mRNA-(lipid) nanoparticle products

Benefits

• health
• dental
• life
• open PTO
• onsite lunch catering
• commuter support
• work/life flexibility and integration

About the company

Strand Therapeutics is a clinical-stage biotechnology company pioneering programmable mRNA therapeutics. Headquartered in Boston, MA, the company is advancing a pipeline with an initial focus on oncology and autoimmune disease.